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Genome-wide association study of insect bite hypersensitivity in Dutch Shetland pony mares.
Schurink, A; Ducro, B J; Bastiaansen, J W M; Frankena, K; van Arendonk, J A M.
Afiliação
  • Schurink A; Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, the Netherlands. Anouk3.Schurink@wur.nl
Anim Genet ; 44(1): 44-52, 2013 Feb.
Article em En | MEDLINE | ID: mdl-22582722
Insect bite hypersensitivity (IBH) is the most common allergic disease present in horses worldwide. It has been shown that IBH is under genetic control, but the knowledge of associated genes is limited. We conducted a genome-wide association study to identify and quantify genomic regions contributing to IBH in the Dutch Shetland pony population. A total of 97 cases and 91 controls were selected and matched on withers height, coat colour and pedigree to minimise the population stratification. A blood sample was collected from participating Shetland pony mares, their IBH phenotype was scored and the owner filled in a questionnaire. A total of 40 021 single-nucleotide polymorphisms (SNPs) were fitted in a univariable logistic model fitting an additive effect. Analysis revealed no effects of population stratification. Significant associations with IBH were detected for 24 SNPs on 12 chromosomes [-log(10) (P-value) > 2.5]. Odds ratios of allele substitution effects of the unfavourable allele were between 1.94 and 5.95. The most significant SNP was found on chromosome 27, with an odds ratio of 2.31 and with an allele frequency of the unfavourable allele of 0.72 in cases and 0.53 in controls. Genome-wide association studies on additional horse populations are desired to validate the identified associations, to identify the genes involved in IBH and to develop genomic tools to decrease IBH prevalence.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Cavalos / Hipersensibilidade / Mordeduras e Picadas de Insetos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals País/Região como assunto: Europa Idioma: En Revista: Anim Genet Assunto da revista: GENETICA / MEDICINA VETERINARIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Cavalos / Hipersensibilidade / Mordeduras e Picadas de Insetos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals País/Região como assunto: Europa Idioma: En Revista: Anim Genet Assunto da revista: GENETICA / MEDICINA VETERINARIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido