A nomogram to predict individual prognosis in node-negative breast carcinoma.
Eur J Cancer
; 48(16): 2954-61, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22658808
ABSTRACT
BACKGROUND:
Currently, the benefit of chemotherapy (CT) in node-negative breast carcinoma (NNBC) is discussed. The evaluation of classical clinical and histological factors is limited to assess individual outcome. A statistical model was developed to improve the prognostic accuracy of NNBC.METHODS:
A total of 305 node-negative breast carcinomas who underwent surgery (+/- radiotherapy) but no adjuvant treatment were selected. Putative prognosis factors including age, tumour size, oestrogen receptor (ER), progesterone receptor (PgR), Scarff-Bloom-Richardon (SBR) grading, urokinase plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1) and thymidine kinase (TK) were evaluated. The developed model was internally validated using Harrell's concordance index. A prognosis index (PI) was proposed and compared with Adjuvant! Online program.RESULTS:
Age (p < 0.001), pathological tumour size (pT) (p < 0.001), PgR (p = 0.02), and PAI-1 (p ≤ 0.001) were included in the Cox regression model predicting Breast cancer specific survival (BCSS) at 5-years. Internal validation revealed a concordance index of 0.71. A PI score was derived from our nomogram. The PI score was significantly associated with BCSS (hazard ratio (HR) 4.1 for intermediate, p=0.02, HR 8.8, p < 0.001 for high group) as compared to Adjuvant! Online score (HR 1.4, p=0.14).CONCLUSION:
A nomogram can be used to predict probability survival curves for individual breast cancer patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Carcinoma
/
Mastectomia Radical Modificada
/
Mastectomia Segmentar
/
Técnicas de Apoio para a Decisão
/
Nomogramas
/
Linfonodos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Região como assunto:
Europa
Idioma:
En
Revista:
Eur J Cancer
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França