Trajectory clustering of estradiol and follicle-stimulating hormone during the menopausal transition among women in the Study of Women's Health across the Nation (SWAN).
J Clin Endocrinol Metab
; 97(8): 2872-80, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22659249
ABSTRACT
CONTEXT Variability in the pattern of change in estradiol (E2) and FSH levels over the menopause transition has not been well defined. OBJECTIVE:
The current study aimed to determine whether different trajectories of E2 and FSH could be identified and whether race/ethnicity and body mass index were related to the different trajectories.DESIGN:
The Study of Women's Health Across the Nation is a longitudinal observational study of the menopausal transition.SETTING:
Women aged 42-52 yr from seven participating sites were recruited and underwent up to 11 annual visits.PARTICIPANTS:
Postmenopausal women with 12 or more months of amenorrhea that was not due to hysterectomy/oophorectomy and who were not using hormone therapy before the final menstrual period participated in the study. MAIN OUTCOMEMEASURES:
Annual serum E2 and FSH levels anchored to final menstrual period were measured.RESULTS:
Four distinct E2 trajectories and three distinct FSH trajectories were identified. The E2 trajectories were slow decline (26.9%), flat (28.6%), rise/slow decline (13.1%), and rise/steep decline (31.5%). The FSH trajectories were low (10.6%), medium (48.7%), and high (41.7%) rising patterns. Obesity increased the likelihood of a flat E2 and low FSH trajectory for all race/ethnic groups. Normal-weight Caucasian and African-American women tended to follow the rise/steep decline E2 and high FSH trajectories. Normal-weight Chinese/Japanese women tended to follow the slow decline E2 and the high/medium FSH trajectories.CONCLUSIONS:
E2 and FSH trajectories over the menopausal transition are not uniform across the population of women. Race/ethnicity and body mass index affect the trajectory of both E2 and FSH change over the menopausal transition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Menopausa
/
Estradiol
/
Hormônio Foliculoestimulante
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos