A gene therapy approach to eliminate HIV-1-infected cells.
J Calif Dent Assoc
; 40(5): 402-6, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22685947
The ideal therapy for HIV infection requires a method to eliminate all HIV-harboring cells in the infected individual. The authors are developing an HIV-specific promoter to drive the expression of suicide genes that would induce cell death specifically in HIV-infected cells. The authors constructed a promoter that is 100-fold more responsive to the HIV transcriptional activator, Tat, than cellular transcription factors, using a plasmid expressing luciferase under the control of the mutated LTR promoter.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Terapia Genética
/
Infecções por HIV
/
HIV-1
Limite:
Humans
Idioma:
En
Revista:
J Calif Dent Assoc
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos