Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens.
J Inflamm (Lond)
; 9(1): 23, 2012 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-22691598
ABSTRACT
Glycogen synthase kinase 3ß (GSK3ß) plays a fundamental role during the inflammatory response induced by bacteria. Depending on the pathogen and its virulence factors, the type of cell and probably the context in which the interaction between host cells and bacteria takes place, GSK3ß may promote or inhibit inflammation. The goal of this review is to discuss recent findings on the role of the inhibition or activation of GSK3ß and its modulation of the inflammatory signaling in monocytes/macrophages and epithelial cells at the transcriptional level, mainly through the regulation of nuclear factor-kappaB (NF-κB) activity. Also included is a brief overview on the importance of GSK3 in non-inflammatory processes during bacterial infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Inflamm (Lond)
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
México