[Histocompatibility antigens and acute vascular purpura]. / Antígenos de histocompatibilidad y púrpura vascular aguda.
Bol Med Hosp Infant Mex
; 47(9): 620-3, 1990 Sep.
Article
em Es
| MEDLINE
| ID: mdl-2271123
ABSTRACT
INTRODUCTION:
Some kidney diseases are associated to HLA antigens. Nyulassy found an increase in HLA-B35 in patients with Henoch-Schönlein's purpura suffering nephritis (HSP-N). Our study searched for associations of HLA antigens and anaphylactoid purpura nephritis in Mexican mestizo patients. MATERIAL ANDMETHODS:
HLA-A,B, and C antigens were detected by two-step microcytotoxicity in 22 patients with HSP-N and compared to those of 665 healthy subjects of the same ethnic background.RESULTS:
A significant association was found between HSP-N and HLA-Aw19 single (pc less than 0.05) or in haplotype form (Aw19-B35) (pc less than 0.005). HLA B35 alone was associated to HSP-N but only at non corrected level (pc less than 0.05).DISCUSSION:
The significant association between HLA-Aw19 and Aw19-B35 and HSP-N may indicate a risk factor in Mexican mestizo patients to develop this case.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasculite por IgA
/
Antígenos HLA
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Mexico
Idioma:
Es
Revista:
Bol Med Hosp Infant Mex
Ano de publicação:
1990
Tipo de documento:
Article