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The transient effect of interictal spikes from a frontal focus on language-related gamma activity.
Brown, Erik C; Matsuzaki, Naoyuki; Asano, Eishi.
Afiliação
  • Brown EC; School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Epilepsy Behav ; 24(4): 497-502, 2012 Aug.
Article em En | MEDLINE | ID: mdl-22749027
Interictal spike activity arising from an epileptic focus may cause transient subclinical changes in language function. We retrospectively studied four patients with a seizure focus of the left frontal lobe who underwent language mapping via electrocorticography. In three patients, we could group language task trials into 'spike' and 'non-spike' trials, based upon occurrence of spikes arising from the seizure onset zone during presentation of question stimuli. In one patient, we demonstrated a reduction in language-related gamma activity (80-100Hz) at one dorsal superior frontal site outside the seizure onset zone; reduction in mean peak amplitude of 58.4% of baseline reference (95% C.I.: 31.6% to 85.1%). This site was located near the seizure onset zone and was associated with the greatest spike rate among sites of similar function. This is the first preliminary study to show an effect of interictal spikes upon language-related gamma activity of the lateral frontal lobe.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia / Ondas Encefálicas / Lobo Frontal / Idioma Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia / Ondas Encefálicas / Lobo Frontal / Idioma Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Epilepsy Behav Assunto da revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos