[Intravenous treatment with streptokinase of acute myocardial infarction. II. Effect of patency of the artery supplying the infarction area on the infarction size and post-infarction impairement of left-ventricular function]. / Dozylne leczenie streptokinaza swiezego zawalu serca. II. Wplyw droznosci tetnicy zaopatrujacej obszar zawalu na mase zawalu i pozawalowy ubytek czynnosci lewej komory.
Kardiol Pol
; 33(1): 3-7, 1990 Jan.
Article
em Pl
| MEDLINE
| ID: mdl-2277475
ABSTRACT
153 patients with a first acute myocardial infarction underwent the study. 90 of them received 1.000.000 units of streptokinase intravenously, followed by intravenous heparin administration for 5-7 days. The control group consisted of 63 remaining. In all patients serum CK-MB activity was determined every 4 hours for 72 hours the infarct mass was calculated from the obtained curves. In 118 patients selective coronarography and left ventriculography was performed in the 2-nd or 3-rd week of hospitalisation. Left ventricular ejection fraction (E.F.) and dyssynergy index were calculated from ventriculographic data. Coronarography revealed a patent infarct-related artery in 76.7% of patients treated with streptokinase and in 44.4% of the control group (p less than 0.001). Among patients with a patent infarct-related artery an early peak of serum CK-MB activity (suggesting early recanalisation) occurred in 72.2% of streptokinase patients but in only 42.1% of the control group. Patients with a patent infarct-related artery had a significantly lower infarct mass (45 +/- 28 g vs 56 +/- 30 g), a lower left ventricular dyssynergy index (229 +/- 243 vs 348 +/- 247) and a significantly higher E.F. (63 +/- 12% vs 54 +/- 15%) compared with patients with an occluded artery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estreptoquinase
/
Grau de Desobstrução Vascular
/
Cardiomiopatia Dilatada
/
Função Ventricular Esquerda
/
Vasos Coronários
/
Infarto do Miocárdio
/
Miocárdio
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
Pl
Revista:
Kardiol Pol
Ano de publicação:
1990
Tipo de documento:
Article