Sialyl Lewis(x): a "pre-organized water oligomer"?
Angew Chem Int Ed Engl
; 51(29): 7327-31, 2012 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-22782926
ABSTRACT
Organized and released Sialyl Lewis(x) (sLe(x)) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Água
/
Selectina E
Limite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Suíça