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Synthesis of enantiopure, trisubstituted cryptophane-A derivatives.
Org Lett ; 14(14): 3580-3, 2012 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-22783828
ABSTRACT
The efficient synthesis of enantiopure, trisubstituted cryptophane-A derivatives, organic host molecules with unusually high xenon affinity, is reported. Synthesis and chromatographic separation of (±) tri-Mosher's acid substituted cryptophane diastereomers gave ready access to the enantiopure cryptophanes, which are critical components in the design of enantiomerically pure (129)Xe biosensors. Hyperpolarized (129)Xe NMR spectroscopy identified single resonances for both trisubstituted cryptophane diastereomers that were separated by 9.5 ppm. This highlights opportunities for using enantiopure xenon biosensors in the simultaneous detection of (129)Xe in different biochemical environments.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Compostos Policíclicos Idioma: Inglês Revista: Org Lett Assunto da revista: Bioquímica Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Estados Unidos