Pathological gambling from dopamine agonist and deep brain stimulation of the nucleus tegmenti pedunculopontine.
BMJ Case Rep
; 20102010 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-22798481
ABSTRACT
In patients with Parkinson's disease, aberrant or excessive dopaminergic stimulation is commonly indicated as the trigger factor in unmasking impulse control disorders (ICDs) such as pathological gambling. We had the opportunity to follow a patient who experienced Parkinson's disease 7 years ago when he was using pramipexole and again, recently, when he was treated with levodopa (L-dopa) and low frequency stimulation of the nucleus of the pedunculopontine tegmentus (PPTg) but no dopamine agonists. The same patient had shown, when studied with fluorodeoxyglucose-positron emission tomography in the condition PPTg-ON, a peculiar increased activity in the left ventral striatum. This case report confirms that, in a predisposed personality, ICD may arise from the perturbation of endogenous pathways, which connect the brainstem to the basal ganglia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dopaminérgicos
/
Levodopa
/
Núcleo Tegmental Pedunculopontino
/
Estimulação Encefálica Profunda
/
Jogo de Azar
/
Antiparkinsonianos
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália