The histopathological comparison of L-carnitine with amifostine for protective efficacy on radiation-induced acute small intestinal toxicity.
J Cancer Res Ther
; 8(2): 260-5, 2012.
Article
em En
| MEDLINE
| ID: mdl-22842372
ABSTRACT
BACKGROUND:
The aim of the study was to compare the protective efficacy of l-carnitine (LC) to amifostine on radiation-induced acute small intestine damage. MATERIALS ANDMETHODS:
Thirty, 4-week-old Wistar albino rats were randomly assigned to four groups - Group 1 control (CONT, n = 6), Group 2 irradiation alone (RT, n = 8), Group 3 amifostine plus irradiation (AMI+RT, n = 8), and Group 4 l-Carnitine plus irradiation (LC+RT, n = 8). The rats in all groups were irradiated individually with a single dose of 20 Gy to the total abdomen, except those in CONT. LC (300 mg/kg) or amifostine (200 mg/kg) was used 30 min before irradiation. Histopathological analysis of small intestine was carried out after euthanasia.RESULTS:
Pretreatment with amifostine reduced the radiation-induced acute degenerative damage (P = 0.009) compared to the RT group. Pretreatment with LC did not obtain any significant difference compared to the RT group. The vascular damage significantly reduced in both of the AMI+RT (P = 0.003) and LC+RT group (P = 0.029) compared to the RT group. The overall damage score was significantly lower in the AMI+RT group than the RT group (P = 0.009). There was not any significant difference between the LC+RT and RT group.CONCLUSIONS:
Amifostine has a marked radioprotective effect against all histopathological changes on small intestinal tissue while LC has limited effects which are mainly on vascular structure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
/
Protetores contra Radiação
/
Carnitina
/
Amifostina
/
Intestino Delgado
Limite:
Animals
Idioma:
En
Revista:
J Cancer Res Ther
Assunto da revista:
NEOPLASIAS
/
TERAPEUTICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Turquia