Odor-evoked activity in the mouse lateral entorhinal cortex.
Neuroscience
; 223: 12-20, 2012 Oct 25.
Article
em En
| MEDLINE
| ID: mdl-22871522
ABSTRACT
The entorhinal cortex is a brain area with multiple reciprocal connections to the hippocampus, amygdala, perirhinal cortex, olfactory bulb and piriform cortex. As such, it is thought to play a large role in the olfactory memory process. The present study is the first to compare lateral entorhinal and anterior piriform cortex odor-evoked single-unit and local field potential activity in mouse. Recordings were made in urethane-anesthetized mice that were administered a range of three pure odors and three overlapping odor mixtures. Results show that spontaneous as well as odor-evoked unit activity was lower in lateral entorhinal versus piriform cortex. In addition, units in lateral entorhinal cortex were responsive to a more restricted set of odors compared to piriform. Conversely, odor-evoked power change in local field potential activity was greater in the lateral entorhinal cortex in the theta band than in piriform. The highly odor-specific and restricted firing in lateral entorhinal cortex suggests that it may play a role in modulating odor-specific, experience- and state-dependent olfactory coding.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Córtex Entorrinal
/
Potenciais Somatossensoriais Evocados
/
Neurônios
/
Odorantes
Limite:
Animals
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos