KHC-4 anti-cancer effects on human PC3 prostate cancer cell line.
Am J Chin Med
; 40(5): 1063-71, 2012.
Article
em En
| MEDLINE
| ID: mdl-22928835
ABSTRACT
A bicyclic chemical structure, such as that found in flavonoids, was discovered to have anti-cancer activity. Further synthetic structural modification created a series of 2-phenyl-4-quinolone analogs, especially KHC-4, with the same bicyclic chemical structure. This new structure was reported to have stronger anti-cancer activity. In KHC-4 treatments for 72 h on human prostate cancer PC3 cells, cytotoxic effects (IC(50) =0.1 µM) increased dose dependently, causing Cdk1/cyclin B1 complex activity mannered cell cycle and proliferation. KHC-4 treatments suppressed Bcl-2 and Bcl-xL protein levels and upregulated Bax. At the same concentration, pro-caspase 9 protein was cleaved to an activated form, leading to cell apoptosis. Furthermore, the MMP-2 protein levels also decreased through KHC-4 treatment in PC3. In conclusion, KHC-4 presents great prostate cancer therapeutic effects for cell proliferation inhibition, induction of apoptosis and protection against tumor migration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Flavonoides
/
Morfolinas
/
Quinolonas
/
Antineoplásicos
Limite:
Humans
/
Male
Idioma:
En
Revista:
Am J Chin Med
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Taiwan