Neurological perspectives on voltage-gated sodium channels.
Brain
; 135(Pt 9): 2585-612, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22961543
ABSTRACT
The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Sódio
/
Ativação do Canal Iônico
Limite:
Animals
Idioma:
En
Revista:
Brain
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido