Phycobiliproteins or C-phycocyanin of Arthrospira (Spirulina) maxima protect against HgCl(2)-caused oxidative stress and renal damage.
Food Chem
; 135(4): 2359-65, 2012 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-22980813
ABSTRACT
Our objective was to determine if the phycobiliproteins of Arthrospira (Spirulina) maxima protect renal cells against mercury-caused oxidative stress and cellular damage in the kidney. We used 40 male mice that were assigned into eight groups (1) a control group that received 100mM phosphate buffer (PB) ig and 0.9% saline ip, (2) PB+HgCl(2) (5mg/kg ip), (3) PB plus phycobiliproteins (100mg/kg ig), (4) PB plus C-phycocyanin (100mg/kg ig), and four groups receiving HgCl(2)+phycobiliproteins or C-phycocyanin (50, and 100mg/kg ig). The left kidneys were used to determine lipid peroxidation, quantification of reactive oxygen species, and reduced glutathione and oxidised content. The right kidneys were processed for histology. The HgCl(2) caused oxidative stress and cellular damage. All doses of phycobiliproteins or C-phycocyanin prevented enhancement of oxidative markers and they protected against HgCl(2)-caused cellular damage.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ficocianina
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Proteínas de Bactérias
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Cianobactérias
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Estresse Oxidativo
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Substâncias Protetoras
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Ficobiliproteínas
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Rim
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Nefropatias
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Cloreto de Mercúrio
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Food Chem
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
México