[Fibrinolysis components and angiogenesis regulation by example of burn-induced corneal neovascularization in rabbits].
Vestn Oftalmol
; 128(4): 62-5, 2012.
Article
em Ru
| MEDLINE
| ID: mdl-22994111
ABSTRACT
Increased plasminogen level in tear fluid was found within 28 days and increased plasmin activity in 1-3 and 21 days after alkali burn of cornea, this is the time of cornel ulcers development. Increased plasminogen level and plasmin activity in cornea, conjunctiva and intraocular fluid was found in three days after trauma. Subconjunctival injections of angiostatin K1-4,5 (a product of plasminogen metabolism) during 3 weeks resulted in significant suppression of corneal neovascularization within 14 days and of active branching of the vessels in the following. The use of angiostatin reduced depth and area of corneal ulcers. Obtained data shows the promising potential of development of medications based on angiostatin K1-4,5 for suppression of corneal neovascularization and for treatment of diseases associated with corneal ulceration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fluxo Sanguíneo Regional
/
Úlcera da Córnea
/
Queimaduras Oculares
/
Neovascularização da Córnea
/
Córnea
/
Angiostatinas
/
Neovascularização Patológica
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
Ru
Revista:
Vestn Oftalmol
Ano de publicação:
2012
Tipo de documento:
Article