Increase in mitochondrial DNA copy number in response to ochratoxin A and methanol-induced mitochondrial DNA damage in Drosophila.
Bull Environ Contam Toxicol
; 89(6): 1129-32, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23001422
ABSTRACT
The current study examined the effects of ochratoxin A (OTA) and methanol on mitochondrial DNA (mtDNA). The results showed that methanol application caused approximately 29 % more damage than the control group, and that there were no significant differences among the other groups in terms of mtDNA damage. The application of 0.04 ng/mL OTA and 0.04 ng/mL OTA with methanol increased mtDNA copy number compared with the control and 0.005 ng/mL OTA with methanol groups. The copy number in the 0.04 ng/mL OTA group was approximately 16 % greater than in the control.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
Carcinógenos
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Metanol
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Ocratoxinas
Limite:
Animals
Idioma:
En
Revista:
Bull Environ Contam Toxicol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA