Increase in mitochondrial DNA copy number in response to ochratoxin A and methanol-induced mitochondrial DNA damage in Drosophila.

ABSTRACT

The current study examined the effects of ochratoxin A (OTA) and methanol on mitochondrial DNA (mtDNA). The results showed that methanol application caused approximately 29 % more damage than the control group, and that there were no significant differences among the other groups in terms of mtDNA damage. The application of 0.04 ng/mL OTA and 0.04 ng/mL OTA with methanol increased mtDNA copy number compared with the control and 0.005 ng/mL OTA with methanol groups. The copy number in the 0.04 ng/mL OTA group was approximately 16 % greater than in the control.