[Molecular mechanisms of development of cerebral tolerance to ischemia (Review. Part 2)].
Vestn Ross Akad Med Nauk
; (7): 20-9, 2012.
Article
em Ru
| MEDLINE
| ID: mdl-23013000
ABSTRACT
In the 2nd part the authors describe in details the main aspects of protective effect of preconditioning of the brain inhibition of programmed cell death, weakening of phenomenon of excitotoxicity, activation of endogenous antioxidant systems, anti-inflammatory effects, modulation of glial cell function, changes in regional blood flow and vascular reactivity. In addition, data analysis on the impact of preconditioning on brain neurogenesis, the state of the blood-brain barrier, ion homeostasis and metabolism of neurons is presented. Review emphasizes the role of microRNAs in mechanisms of ischemic tolerance of brain. Profound understanding of molecular mechanisms of increased tolerance of brain to ischemic and reperfusion injury requires the implementation of this phenomenon in clinical practice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Traumatismo por Reperfusão
/
Isquemia Encefálica
/
Precondicionamento Isquêmico
/
Neurônios
Limite:
Humans
Idioma:
Ru
Revista:
Vestn Ross Akad Med Nauk
Assunto da revista:
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article