The impact of tacrolimus as rescue therapy in children using a double immunosuppressive regimen after heart transplantation.
Transplant Proc
; 44(8): 2483-5, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23026625
ABSTRACT
BACKGROUND:
Organ transplant recipients with refractory rejection or intolerance to the prescribed immunosuppressant may respond to rescue therapy with tacrolimus. We sought to evaluate the clinical outcomes of children undergoing heart transplantation who required conversion from a cyclosporine-based, steroid-free therapy to a tacrolimus-based regimen.METHODS:
We performed a prospective, observational, cohort study of 28 children who underwent conversion from cyclosporine-based, steroid-free therapy to a tacrolimus-based therapy for refractory or late rejection or intolerance to cyclosporine.RESULTS:
There was complete resolution of refractory rejection episodes and adverse side effects in all patients. The incidence rate (×100) of rejection episodes before and after conversion was 7.98 and 2.11, respectively (P ≤ .0001). There was a 25% mortality rate in patients using tacrolimus after a mean period of 60 months after conversion.CONCLUSION:
Tacrolimus is effective as rescue therapy for refractory rejection and is a therapeutic option for pediatric patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Coração
/
Tacrolimo
/
Ciclosporina
/
Rejeição de Enxerto
/
Imunossupressores
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Transplant Proc
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil