Behavioral deficits in rats with minimal cortical hypoplasia induced by methylazoxymethanol acetate.
Pediatrics
; 85(3 Pt 2): 432-6, 1990 Mar.
Article
em En
| MEDLINE
| ID: mdl-2304805
ABSTRACT
Methylazoxymethanol, a short-acting antimitotic agent, produces marked cortical hypoplasia in fetuses when injected into pregnant rats. These offspring also have increased cortical concentrations of biogenic amines associated with hyperactivity and learning deficits. In this experiment, rats with a relatively mild degree of methylazoxymethanol-induced cortical hypoplasia were studied to determine whether these neurochemical and behavioral abnormalities persisted. Sprague-Dawley pregnant rats were injected intraperitoneally on day 15 of gestation with methylazoxymethanol acetate (25 mg/kg). Total brain weight was reduced by 12% and cortical slab weight by 28% in methylazoxymethanol-exposed offspring. They were more active than control rats and showed a trend toward slower learning in a swim maze. Affected offspring had increased cortical concentrations of norepinephrine, 5-hydroxyindoleacetic acid, and glycine. There was no significant difference in the concentrations of serotonin gamma-aminobutyric acid, aspartic acid, glutamic acid, or glutamine. Methylazoxymethanol-lesioned animals with mild cortical hypoplasia remained measurably hyperactive and may serve as a model for the study of neurotransmitter and neuropathologic abnormalities associated with hyperactivity in children with microcephaly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno do Deficit de Atenção com Hiperatividade
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Compostos Azo
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Acetato de Metilazoximetanol
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Modelos Animais de Doenças
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Deficiências da Aprendizagem
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Microcefalia
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Pediatrics
Ano de publicação:
1990
Tipo de documento:
Article