Lipoic acid attenuates the expression of adhesion molecules by increasing endothelial nitric-oxide synthase activity.
Mol Biol Rep
; 40(1): 377-82, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23054010
ABSTRACT
We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothelial cells were exposed to high glucose in the absence and presence of LA. Coincubation of endothelial cells with high glucose for 24 h resulted in a significant increase of monocyte-endothelial cell adhesion and the expression of ICAM-1 (P < 0.01). These effects were abolished by LA and LA significantly increased eNOS activities (P < 0.01). These findings suggested that LA may play a role in inhibiting expression of adhesion molecules by increasing eNOS activities.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular
/
Ácido Tióctico
/
Células Endoteliais
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
Mol Biol Rep
Ano de publicação:
2013
Tipo de documento:
Article