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Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents.
Venkatraj, Muthusamy; Ariën, Kevin K; Heeres, Jan; Joossens, Jurgen; Messagie, Jonas; Michiels, Johan; Van der Veken, Pieter; Vanham, Guido; Lewi, Paul J; Augustyns, Koen.
Afiliação
  • Venkatraj M; Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
Bioorg Med Chem Lett ; 22(23): 7174-8, 2012 Dec 01.
Article em En | MEDLINE | ID: mdl-23084903
ABSTRACT
This letter reports the synthesis and structure-activity relationship (SAR) study of a series of triazine dimers as novel antiviral agents. These compounds were obtained through a bivalent ligand approach in which two triazine moieties are covalently connected by suitable linkers. Several compounds showed submicromolar activity against wild-type HIV-1 and moderate activity against single mutant strains.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazinas / Inibidores da Transcriptase Reversa Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazinas / Inibidores da Transcriptase Reversa Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Bélgica