LC-MS systems for quantitative bioanalysis.
Bioanalysis
; 4(19): 2391-9, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23088465
ABSTRACT
LC-MS has become the method-of-choice in small-molecule drug bioanalysis (molecular mass <800 Da) and is also increasingly being applied as an alternative to ligand-binding assays for the bioanalytical determination of biopharmaceuticals. Triple quadrupole MS is the established bioanalytical technique due to its unpreceded selectivity and sensitivity, but high-resolution accurate-mass MS is recently gaining ground due to its ability to provide simultaneous quantitative and qualitative analysis of drugs and their metabolites. This article discusses current trends in the field of bioanalytical LC-MS (until September 2012), and provides an overview of currently available commercial triple quadrupole MS and high-resolution LC-MS instruments as applied for the bioanalysis of small-molecule and biopharmaceutical drugs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Massas
/
Preparações Farmacêuticas
/
Proteínas
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Cromatografia Líquida de Alta Pressão
Tipo de estudo:
Qualitative_research
Idioma:
En
Revista:
Bioanalysis
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Holanda