[Dexmedetomidine and clonidine: a review of their pharmacodynamy to define their role for sedation in intensive care patients]. / Dexmédétomidine et clonidine : revue de leurs propriétés pharmacodynamiques en vue de définir la place des agonistes alpha-2 adrénergiques dans la sédation en réanimation.
Ann Fr Anesth Reanim
; 31(11): 876-96, 2012 Nov.
Article
em Fr
| MEDLINE
| ID: mdl-23089375
ABSTRACT
Alpha-2 adrenergic agonists ("alpha-2 agonists") present multiple pharmacodynamic effects rousable sedation, decreased incidence of delirium in the setting of critical care, preservation of respiratory drive, decreased whole body oxygen consumption, decreased systemic and pulmonary arterial impedance, improved left ventricular systolic and diastolic function, preserved vascular reactivity to exogenous catecholamines, preserved vasomotor baroreflex with lowered set point, preserved kidney function, decreased protein catabolism. These pharmacodynamic effects explain the interest for these drugs in the critical care setting. However, their exact role for sedation in critically ill-patients remains open for further studies. Given the few double-blind randomized multicentric trials available, the present non exhaustive analysis of the literature aims at presenting the utilization of alpha-2 agonists as potential first-line sedative agents, in the critical care setting. Suggestions regarding the use of alpha-2 agonists as sedatives are detailed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clonidina
/
Cuidados Críticos
/
Dexmedetomidina
/
Sedação Profunda
/
Agonistas de Receptores Adrenérgicos alfa 2
/
Analgésicos
/
Hipnóticos e Sedativos
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
Fr
Revista:
Ann Fr Anesth Reanim
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França