Effect of lead on the activity of erythrocyte porphobilinogen deaminase in vivo and in vitro.
Toxicol Lett
; 50(2-3): 137-42, 1990 Feb.
Article
em En
| MEDLINE
| ID: mdl-2309232
ABSTRACT
The effect of lead on the activity of erythrocyte porphobilinogen deaminase (PBGD) in vivo and in vitro was investigated using blood specimens obtained from controls and lead-exposed workers. When lead nitrate was added to the incubation mixture at a final concentration of 10(-4) M, 83% inhibition of erythrocyte PBGD activity was found. However, in workers occupationally exposed to lead, no inhibition of erythrocyte PBGD activity was detected. This finding indicates that the erythrocyte PBGD test is not useful for evaluating exposure to lead in workers. In addition, the in vitro study confirmed that mercuric chloride strongly inhibits erythrocyte PBGD activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidroximetilbilano Sintase
/
Eritrócitos
/
Amônia-Liases
/
Chumbo
/
Nitratos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão