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Effect of immobilisation stress on lipid peroxidation and lipid profile in rabbits.
Lata, Hem; Ahuja, G K; Narang, A P S; Walia, Lily.
Afiliação
  • Lata H; Department of physiology, Dayanand Medical College and Hospital, 141001 Ludhiana, India.
Indian J Clin Biochem ; 19(2): 1-4, 2004 Jul.
Article em En | MEDLINE | ID: mdl-23105447
Stress is one of the basic factors in the aetiology of a number of diseases such as atherosclerosis, coronary heart disease, aging, liver disease etc. Hence this work was designed to study the effect of stress in the form of forced immobilisation stress on lipid peroxidation and lipid profile in rabbits. The study was conducted in 25 healthy rabbits of either sex. Rabbits were subjected to forced immobilisation for two hours everyday for consecutive seven days. Blood samples were collected on day 1, 3 and 7 after immobilisation period. Malondialdehyde (MDA), a marker of lipid peroxidation was estimated by TBA assay method. Lipid profile was analysed by multichannel autoanalyser. There was statistically significant increase in MDA, total cholesterol, LDL, VLDL and triglycerides with immobilisation. These findings indicate that stress in the form of forced immobilisation increases lipid peroxidation and alter lipid profile, which may be responsible for pathophysiology of various diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Indian J Clin Biochem Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Índia País de publicação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Indian J Clin Biochem Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Índia País de publicação: Índia