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Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: a new light for treatment of TARDBP/TDP-43 proteinopathies.
Wang, I-Fang; Tsai, Kuen-Jer; Shen, Che-Kun James.
Afiliação
  • Wang IF; Institute of Life Science, National Defense Medical Center, Taipei, Taiwan.
Autophagy ; 9(2): 239-40, 2013 Feb 01.
Article em En | MEDLINE | ID: mdl-23108236
ABSTRACT
The administration of rapamycin, an MTOR-dependent autophagy activator, for the treatment of neurodegenerative diseases has been tested in several animal models. Thus, whether autophagy activation would lead to the clearance of abnormal accumulation of aggregated proteins in neurodegenerative diseases is worthy of exploration. We have recently shown that rapamycin administration at the early pathological stage of a mouse model with frontotemporal lobar dementia (FTLD-U) characterized with cytoplasmic TARDBP/TDP-43(+)/ubiquitin(+) inclusions (UBIs) in the diseased neurons could rescue the learning/memory deficiency and the abnormal motor function disorder of the mice. This was accompanied by a decreased level of CASP3/caspase-3 and a reduction of the neuronal loss in the mouse forehead. Moreover, autophagy activation at a late pathological stage also could improve motor function, which was accompanied by a reduction of the TARDBP(+) UBIs. This study has set the principal for therapy of neurodegenerative diseases with the TARDBP protein, i.e., amyotrophic lateral sclerosis (ALS)-TDP and FTLD-TDP43, with the use of autophagy activators.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas de Ligação a DNA / Demência Frontotemporal / Neurônios Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Autophagy Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas de Ligação a DNA / Demência Frontotemporal / Neurônios Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Autophagy Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Taiwan