Extrahepatic spread of hepatocellular carcinoma.
Panminerva Med
; 54(4): 313-22, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23123584
ABSTRACT
Hepatocellular carcinoma (HCC) is a major health problem. The treatment of HCC depends on the tumour stage and on the severity of underlying cirrhosis, however, a majority of HCC patients have advanced disease at presentation. In recent years extra-hepatic spread (ES) of HCC seems to have been observed more frequently than in the past even if few data exist in literature on prevalence, clinical presentation and prognosis of patients with HCC ES. Aim of this brief review is underline the main concerns, pitfalls and warnings in practicing with these patients. ES of HCC are not rare, and the probability of finding ES is higher in patients with advanced intra-hepatic HCC. The more frequent ES sites are lung lymph nodes and bones, but also the head and neck district can be affected. The prognosis of HCC patients with ES is poor and sorafenib seems to be the only therapeutic option.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Fenilureia
/
Niacinamida
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Panminerva Med
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália