[Effect of pamidronate on cementoclast and osteoclast differentiation factor expression during orthodontic tooth movement in rats].
Shanghai Kou Qiang Yi Xue
; 21(5): 495-500, 2012 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-23135176
ABSTRACT
PURPOSE:
To investigate the influence of pamidronate on cementoclast and osteoclast differentiation factor(ODF) expression during orthodontic tooth movement in rats.METHODS:
24 female, 6-week-old SPF Wistar rats were selected and the animal models for orthodontic tooth movement were established. Each rat's maxillary was divided into experimental side and control side. Pamidronate(50 µL) was injected into the sub-periosteum area adjacent to the left upper first molar(experimental side) every 3 days during the experiment, while 0.9%NS(50 µL) was injected into the corresponding area of the control side. The rats were executed in batch on the 3rd, 7th and 14th day respectively during the orthodontic treatment for detecting the amount of cementoclast and the expression of ODF in the periodontal tissues. All statistical analysis was performed using PASW Statistics 18 software package.RESULTS:
The amount of cementoclasts was significantly less in the experimental side than that in the control side on the 7th and 14th days(P<0.05). The expression of ODF was significantly less in the experimental side than that in the control side on the 7th and 14th days(P<0.05).CONCLUSIONS:
Local injection of pamidronate can reduce the number of cementoclast and the expression of ODF.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas de Movimentação Dentária
/
Ligante RANK
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Shanghai Kou Qiang Yi Xue
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China