Induction of skin sensitization is augmented in Nrf2-deficient mice.
Arch Toxicol
; 87(4): 763-6, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23143620
ABSTRACT
Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alérgenos
/
Dermatite Alérgica de Contato
/
Ensaio Local de Linfonodo
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Fator 2 Relacionado a NF-E2
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Linfonodos
Limite:
Animals
Idioma:
En
Revista:
Arch Toxicol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Holanda