Protective effects of dietary fibre against manganese-induced neurobehavioral aberrations in rats.
Arh Hig Rada Toksikol
; 63(3): 263-70, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-23152376
ABSTRACT
We tested the hypothesis that dietary fibre (DF) has protective effects against manganese (Mn)-induced neurotoxicity. Forty-eight one-month old Sprague-Dawley rats were randomly divided into six groups control, 16 % DF, Mn (50 mg kg-1 body weight), Mn+ 4 % DF, Mn+ 8 % DF, and Mn+ 16 % DF. After oral administration of Mn (as MnCl2) by intragastric tube during one month, we determined Mn concentrations in the blood, liver, cerebral cortex, and stool and tested neurobehavioral functions. Administration of Mn was associated with increased Mn concentration in the blood, liver, and cerebral cortex and increased Mn excretion in the stool. Aberrations in neurobehavioral performance included increases in escape latency and number of errors and decrease in step-down latency. Irrespective of the applied dose, the addition of DF in forage decreased tissue Mn concentrations and increased Mn excretion rate in the stool by 20 % to 35 %. All neurobehavioral aberrations were also improved. Our findings show that oral exposure to Mn may cause neurobehavioral abnormalities in adult rats that could be efficiently alleviated by concomitant supplementation of DF in animal feed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Fibras na Dieta
/
Substâncias Protetoras
/
Intoxicação por Manganês
/
Doenças do Sistema Nervoso
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Arh Hig Rada Toksikol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China