Three-component, one-pot sequential synthesis of functionalized cyclazines: 3H-1,2a1,3-triazaacenaphthylenes.
J Org Chem
; 77(23): 10745-51, 2012 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-23167671
ABSTRACT
An efficient tandem route to the synthesis of 3H-1,2a(1),3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)/Ag(2)CO(3)-catalyzed, three-component domino reaction. This in turn will set the stage for a wide application of this useful reaction for the synthesis of structurally diverse polyheterocyclic skeletons containing the imidazo[1,2-a]pyridine privileged structure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Compostos Aza
/
Acenaftenos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2012
Tipo de documento:
Article