[The role of microRNAs in the pathogenesis of cervical cancer and its relationship to HPV].

ABSTRACT

A lot of miRNAs have participated in the regulation of numerous biological processes such as cell proliferation, apoptosis, invasion and migration in cervical cancer, and closely associated with prognosis and susceptibility of cervical cancer. The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a, subsequently contribute to the initiation and progression of cervical cancer. In turn, some miRNAs such as miR-203 and miR-125b also play roles in the regulation of HPV DNA duplication. In addition, the latest advances on miRNA basic research and its potential significance in the diagnosis and treatment of malignant tumors are also reviewed in this paper.