Your browser doesn't support javascript.
loading
Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy.
Nakajima, Kazuo; Yin, Xiling; Takei, Yosuke; Seog, Dae-Hyun; Homma, Noriko; Hirokawa, Nobutaka.
Afiliação
  • Nakajima K; Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo 113-0033, Japan.
Neuron ; 76(5): 945-61, 2012 Dec 06.
Article em En | MEDLINE | ID: mdl-23217743
KIF5 (also known as kinesin-1) family members, consisting of KIF5A, KIF5B, and KIF5C, are microtubule-dependent molecular motors that are important for neuronal function. Among the KIF5s, KIF5A is neuron specific and highly expressed in the central nervous system. However, the specific roles of KIF5A remain unknown. Here, we established conditional Kif5a-knockout mice in which KIF5A protein expression was postnatally suppressed in neurons. Epileptic phenotypes were observed by electroencephalogram abnormalities in knockout mice because of impaired GABA(A) receptor (GABA(A)R)-mediated synaptic transmission. We also identified reduced cell surface expression of GABA(A)R in knockout neurons. Importantly, we identified that KIF5A specifically interacted with GABA(A)R-associated protein (GABARAP) that is known to be involved in GABA(A)R trafficking. KIF5A regulated neuronal surface expression of GABA(A)Rs via an interaction with GABARAP. These results provide an insight into the molecular mechanisms of KIF5A, which regulate inhibitory neural transmission.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cinesinas / Receptores de GABA-A / Epilepsia Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cinesinas / Receptores de GABA-A / Epilepsia Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos