New mycotoxins from marine-derived fungus Aspergillus sp. SCSGAF0093.

ABSTRACT

Nine mycotoxins including six aspergillic acid group toxins, aluminiumneoaspergillin (1), zirconiumneoaspergillin (2), aspergilliamide (3), ferrineoaspergillin (5), flavacol (6), neoaspergillic acid (7), and three ochratoxins, ochratoxin A n-butyl ester (4), ochratoxin A (8), ochratoxin A methyl ester (9), were isolated from the fermentation broth of marine gorgonian derived fungus Aspergillus sp. SCSGAF0093. Four of them (1-4) were new mycotoxins, and their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The bio-toxicity of compounds 1-9 were determined by brine shrimp lethality bioassay with median lethal concentration (LC(50)) values of 2.59-205.67 µM. This was the first report about zirconium complex obtained from nature and ochratoxins isolated from marine environment.