New mycotoxins from marine-derived fungus Aspergillus sp. SCSGAF0093.
Food Chem Toxicol
; 53: 46-51, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23220611
ABSTRACT
Nine mycotoxins including six aspergillic acid group toxins, aluminiumneoaspergillin (1), zirconiumneoaspergillin (2), aspergilliamide (3), ferrineoaspergillin (5), flavacol (6), neoaspergillic acid (7), and three ochratoxins, ochratoxin A n-butyl ester (4), ochratoxin A (8), ochratoxin A methyl ester (9), were isolated from the fermentation broth of marine gorgonian derived fungus Aspergillus sp. SCSGAF0093. Four of them (1-4) were new mycotoxins, and their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The bio-toxicity of compounds 1-9 were determined by brine shrimp lethality bioassay with median lethal concentration (LC(50)) values of 2.59-205.67 µM. This was the first report about zirconium complex obtained from nature and ochratoxins isolated from marine environment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazinas
/
Aspergillus
/
Poluentes Químicos da Água
/
Micotoxinas
Limite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China