SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication.
Antiviral Res
; 97(2): 101-7, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23237992
ABSTRACT
Suppressor of cytokine signaling 1 (SOCS1) and suppressor of cytokine signaling 3 (SOCS3) have been thought to block type I interferon (IFN) signaling. We have previously reported that SOCS3 suppresses HCV replication in an mTOR-dependent manner. However, the relationship between SOCS1 and HCV replication remains unclear. Here, we found that overexpression of SOCS1 alone did not have an effect on HCV RNA replication. However, suppression of HCV replication by IFN-α was rescued by SOCS1 overexpression. The upregulation of HCV replication by SOCS1 overexpression in the presence of IFN is likely a result of the impairment of IFN signaling by SOCS1 and subsequent induction of ISGs. Knockdown of SOCS1 alone with specific shRNA enhanced the antiviral effect of IFN compared with negative control. Thus, SOCS1 acts as a suppressor of type I IFN function against HCV.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Interferon-alfa
/
Hepacivirus
/
Proteínas Supressoras da Sinalização de Citocina
/
Interações Hospedeiro-Patógeno
Limite:
Humans
Idioma:
En
Revista:
Antiviral Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China