Amyloid and its association with default network integrity in Alzheimer's disease.
Hum Brain Mapp
; 35(3): 779-91, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-23238869
ABSTRACT
The purpose of this study was to investigate the association between functional connectivity and ß-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Envelhecimento
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Peptídeos beta-Amiloides
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Tomografia por Emissão de Pósitrons
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Doença de Alzheimer
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Neuroimagem Funcional
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Disfunção Cognitiva
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Rede Nervosa
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Hum Brain Mapp
Assunto da revista:
CEREBRO
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Holanda