Tumor-infiltrating B cells and T cells: Working together to promote patient survival.
Oncoimmunology
; 1(9): 1623-1625, 2012 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-23264915
ABSTRACT
We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Oncoimmunology
Ano de publicação:
2012
Tipo de documento:
Article