[Enhancing factors in the cardiotoxicity of anthracyclines]. / Factores coadyuvantes de la toxicidad cardiaca por antraciclínicos.
An Esp Pediatr
; 32(1): 11-4, 1990 Jan.
Article
em Es
| MEDLINE
| ID: mdl-2327660
ABSTRACT
We have studied 60 pediatric patients with different neoplastic diseases, treated with anthracyclines. We have followed them clinically and echocardiographically to detect the cardiotoxicity due to anthracyclines and the enhanced factors promptly. We have detected a more important incidence of cardiomyopathy in patients with non-Hodgkin's lymphoma, osteosarcoma and neuroblastoma despite cumulative doses under 550 mg/m2 of anthracyclines. The 2 first groups were treated with high doses of cyclophosphamide and methotrexate, and neuroblastomas with melphalan. The anthracyclines cardiotoxicity is evaluated around 5% in patients treated with doses under 550 mg/m2, and is increased in case of previous or simultaneous aggressive therapy. Continued echocardiography enables a premature detection of cardiotoxicity in these high risk patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coração
/
Antibióticos Antineoplásicos
/
Cardiomiopatias
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Humans
Idioma:
Es
Revista:
An Esp Pediatr
Ano de publicação:
1990
Tipo de documento:
Article