[Relationship of toll-like receptors 2 and 4 genes polymorphisms with allergic diseases with increased levels of specific IgE].
Tsitol Genet
; 46(6): 59-66, 2012.
Article
em Ru
| MEDLINE
| ID: mdl-23285751
The aim of the research was to identify the role of genes polymorphisms encoding TLR2 (NP_003255.2) and TLR4 (NP_612564.1) in the increase of the specific IgE production level and development of allergic diseases. Genetic typing of genome specific regions was performed by polymerase chain reaction method using specific oligonucleotide primers. The obtained results display that the most significant causative allergens are epidermal and household allergens (epidermis of cat, dog and horse, D. farinae, D. pteronyssinus). The relationship of polymorphisms TLR2 (rs5743708) and TLR4 (rs4986790) with increased production of specific IgE in patients with allergic diseases was also observed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Polimorfismo de Nucleotídeo Único
/
Receptor 2 Toll-Like
/
Receptor 4 Toll-Like
/
Hipersensibilidade
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
Ru
Revista:
Tsitol Genet
Ano de publicação:
2012
Tipo de documento:
Article
País de publicação:
Ucrânia