Biphasic large cell neuroendocrine carcinoma--pure mucinous carcinoma of the gallbladder (MANEC): a unique combination.
Pathologica
; 104(4): 185-9, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-23316622
ABSTRACT
INTRODUCTION:
We report a case of primary combined large cell neuroendocrine carcinoma (LCNEC)--pure mucinous carcinoma of the gallbladder (MANEC)--which represents the first description of this entity.METHODS:
The patient is a 59-year-old Italian male who underwent cholecystectomy under a preoperative diagnosis of cholecystitis with gallstones and gallbladder tumour. During laparotomy, cholecystectomy, liver wedge resection and regional lymph node dissection were performed. The resected gallbladder showed a thickened wall, gallstones and a 4 cm gelatinous, cauliflower-like soft tissue mass.RESULTS:
Following surgery, the gallbladder tumour was diagnosed as a mixed endocrine-exocrine carcinoma. There was evidence of lymph node metastasis or direct liver invasion. The mucin-producing carcinoma was composed of poorly differentiated glandular cells with mucin lakes. The LCNEC was characterized by large cells with prominent nucleoli, coarse chromatin and a high mitotic rate. The cells showed an "organoid" growth pattern with rosette formation and frequent areas of necrosis. Chromogranin A, synaptophysin and CD56 were diffusely and strongly expressed.DISCUSSION:
This case may provide helpful insights regarding the histogenesis of this unusual combination of tumors the concept of a collision tumor between two neoplasms that have arisen in adjacent areas may be the best explanation for its pathogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Neuroendócrino
/
Carcinoma de Células Grandes
/
Adenocarcinoma Mucinoso
/
Neoplasias da Vesícula Biliar
/
Neoplasias Primárias Múltiplas
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pathologica
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália