Peculiar effects of muscarinic M1, M2, and M3 receptor blockers on cardiac chronotropic function in neonatal rats.
Bull Exp Biol Med
; 154(1): 1-2, 2012 Nov.
Article
em En, Ru
| MEDLINE
| ID: mdl-23330075
ABSTRACT
The effects of muscarinic M(1), M(2), and M(3) cholinergic receptor blockade on the regulation of chronotropic function of the heart were studied in vivo in 7-day-old rat pups. Intravenous injection of M(2) receptor blocker gallamine produced no changes in cardiac chronotropy. In contrast, M(1) receptor blocker pirenzepine and M(3) receptor blocker 4DAMP provoked bradycardia. These data attest to the involvement of M(1) and especially M(3) cholinergic receptors in the regulation of cardiac chronotropy in rat pups, which confirms the view on pronounced species-specific and age-related peculiarities in the heart control mechanisms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antagonistas Muscarínicos
/
Receptor Muscarínico M1
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Receptor Muscarínico M2
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Receptor Muscarínico M3
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Frequência Cardíaca
Limite:
Animals
Idioma:
En
/
Ru
Revista:
Bull Exp Biol Med
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Federação Russa
País de publicação:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA