CT brain perfusion protocol to eliminate the need for selecting a venous output function.
AJNR Am J Neuroradiol
; 34(7): 1353-8, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23370476
ABSTRACT
BACKGROUND AND PURPOSE:
In CTP, an arterial input function is used for cerebral blood volume measurement. AIFs are often influenced by partial volume effects resulting in overestimated CBV. A venous output function is manually selected to correct for partial volume. This can introduce variability. Our goal was to develop a CTP protocol that enables AIF selection unaffected by partial volume. MATERIALS ANDMETHODS:
First, the effects of partial volume on artery sizes/types including the MCA were estimated by using a CTP phantom with 9 protocols (section thicknesses of 1, 1.8, and 5 mm and image resolutions of 0.5, 1, and 1.5 mm). Next, these protocols were applied to clinical CTP studies from 6 patients. The influence of the partial volume effect was measured by comparison of the time-attenuation curves from different artery locations with reference veins.RESULTS:
AIFs from MCAs were unaffected by partial volume effects when using high image resolution (1 mm) and medium section thickness (1.8 mm). For the clinical data, a total of 104 arteries and 60 veins was selected. The data confirmed that high image resolution and thin section thickness enable selection of MCAs for AIFs free of partial volume influences. In addition, we found that large veins were not insusceptible to partial volume effects relative to large arteries, questioning the use of veins for partial volume correction.CONCLUSIONS:
A CTP protocol with 1.8-mm section thickness and 1-mm image resolution allows AIF selection unaffected by partial volume effects in MCAs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sanguíneo
/
Veias Cerebrais
/
Intensificação de Imagem Radiográfica
/
Tomografia Computadorizada por Raios X
/
Circulação Cerebrovascular
Tipo de estudo:
Clinical_trials
/
Guideline
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Holanda