Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome.
Ann Behav Med
; 46(1): 31-9, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23436275
ABSTRACT
BACKGROUND:
This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors.METHODS:
The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory-II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels.RESULTS:
Leptin was significantly associated with somatic depressive symptoms (ß = 0.33, P = 0.018), but not total depressive symptoms (ß = 0.27, P = 0.067) or cognitive depressive symptoms (ß = 0.21, P = 0.182), after controlling for age, gender, body mass index, and insulin resistance. Further adjustment for C-reactive protein and interleukin-6 levels did not alter the relationship (ß = 0.32, P = 0.023) between circulating leptin levels and somatic depressive symptoms.CONCLUSIONS:
Leptin is independently associated with somatic depressive symptoms in patients with the metabolic syndrome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Leptina
/
Síndrome Metabólica
/
Depressão
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Behav Med
Assunto da revista:
CIENCIAS DO COMPORTAMENTO
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos