Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats.
Arch Pharm Res
; 36(5): 626-33, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23494565
ABSTRACT
Acute hepatic inflammation is regarded as a hallmark of early stage fibrosis, which can progress to extensive fibrosis and cirrhosis. Sinapic acid is a phenylpropanoid compound that is abundant in cereals, nuts, oil seeds, and berries and has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the anti-inflammatory effect of sinapic acid in carbon tetrachloride (CCl4)-induced acute hepatic injury in rats. Sinapic acid was administered orally (10 or 20 mg/kg) to rats at 30 min and 16 h before CCl4 intoxication. Sinapic acid treatment of rats reduced CCl4-induced abnormalities in liver histology, serum alanine transaminase and aspartate transaminase activities, and liver malondialdehyde levels. In addition, sinapic acid treatment significantly attenuated the CCl4-induced production of inflammatory mediators, including tumor necrosis factor-alpha and interleukin-1ß mRNA levels, and increased the expression of nuclear factor-kappa B (NF-κB p65). Sinapic acid exhibited strong free radical scavenging activity in vitro. Thus, sinapic acid protected the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinapic acid may thus have potential as a therapeutic agent for suppressing hepatic inflammation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tetracloreto de Carbono
/
Sequestradores de Radicais Livres
/
Ácidos Cumáricos
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Doença Hepática Induzida por Substâncias e Drogas
/
Anti-Inflamatórios
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2013
Tipo de documento:
Article