[An immunohistochemical evaluation of Warthin's tumor using the monoclonal anti-human lung adenocarcinoma antibody KM-93 and the anti-human gastric carcinoma antibody KM-231].

ABSTRACT

An immunohistochemical identification of a human lung adenocarcinoma antigen and a gastric carcinoma antigen, detected by means of the monoclonal antibodies (MoAbs) KM-93 and KM-231, respectively, has been investigated in cases of a Warthin's tumor and in normal salivary glands. The ductal basal cells of the excretory duct epithelium in normal salivary glands are characterized by their positive staining to MoAb KM-231, whereas MoAb KM-231 staining is confined to basal tumor cells in cases of Warthin's tumor. Further, MoAb KM-93 staining is slightly positive when luminal tumor cells are present. These results suggest that the histogenesis of Warthin's basal tumor cells might originate in the excretory duct epithelium.