Transcriptional and translational regulation of C/EBPß-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1&#945; proteins at the early and late stages of liver cancer.

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Lewis, Kyle; Sullivan, Emily; Jawanmardi, Nicole; Donehower, Lawrence; Timchenko, Lubov; Timchenko, Nikolai A

Transcriptional and translational regulation of C/EBPß-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Lewis, Kyle; Sullivan, Emily; Jawanmardi, Nicole; Donehower, Lawrence; Timchenko, Lubov; Timchenko, Nikolai A.

Afiliação

Jin J; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030.
Iakova P; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030.
Jiang Y; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030.
Lewis K; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030.
Sullivan E; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030.
Jawanmardi N; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030.
Donehower L; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030.
Timchenko L; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
Timchenko NA; Huffington Center on Aging and Department of Huffington Center on Aging and Departments of Pathology and Immunology, Virology, and Microbiology, Baylor College of Medicine, Houston, Texas 77030. Electronic address: nikolait@bcm.tmc.edu.

J Biol Chem ; 288(20): 14451-14462, 2013 May 17.

Article em En | MEDLINE | ID: mdl-23564453

Assuntos

Proteína beta Intensificadora de Ligação a CCAAT/metabolismo; Histona Desacetilase 1/metabolismo; Neoplasias Hepáticas/metabolismo; Sirtuína 1/metabolismo; Transativadores/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Animais; Sequência de Bases; Proliferação de Células; Dietilnitrosamina/farmacologia; Epigênese Genética; Perfilação da Expressão Gênica; Regulação Neoplásica da Expressão Gênica; Proteínas de Choque Térmico/metabolismo; Humanos; Neoplasias Hepáticas/induzido quimicamente; Camundongos; Modelos Biológicos; Dados de Sequência Molecular; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo; Fatores de Transcrição/metabolismo; Ativação Transcricional

Palavras-chave

C/EBP; Cancer; Cancer Tumor Promoter; Cell Proliferation; Chromatin Immunoprecipitation (ChIP); Cyclin-dependent Kinase (CDK); Epigenetic; Liver; Translation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transativadores / Proteína Supressora de Tumor p53 / Proteína beta Intensificadora de Ligação a CCAAT / Sirtuína 1 / Histona Desacetilase 1 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2013 Tipo de documento: Article

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