Xanthoquinodins from the endolichenic fungal strain Chaetomium elatum.
J Nat Prod
; 76(4): 702-9, 2013 Apr 26.
Article
em En
| MEDLINE
| ID: mdl-23586920
ABSTRACT
Five new xanthoquinodins, A4-A6 (1-3), B4 (4), and B5 (5), were isolated from the crude extract of the endolichenic fungal strain Chaetomium elatum (No. 63-10-3-1), along with three known xanthoquinodins, A1-A3 (6-8). Their structures were determined by detailed spectroscopic analysis and comparison of the NMR data with those of the closely related compounds previously reported. The absolute configuration of 1 was established by X-ray crystallographic analysis and ECD calculation. The cytotoxic activity of all compounds was tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chaetomium
/
Cromonas
/
Antineoplásicos
Limite:
Female
/
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2013
Tipo de documento:
Article