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Intestinal metabolism of T-2 toxin in the pig cecum model.
Wu, Qinghua; Engemann, Anna; Cramer, Benedikt; Welsch, Tanja; Yuan, Zonghui; Humpf, Hans-Ulrich.
Afiliação
  • Wu Q; MOA Key Laboratory of Food Safety Evaluation/National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei, 430070, People's Republic of China.
Mycotoxin Res ; 28(3): 191-8, 2012 Aug.
Article em En | MEDLINE | ID: mdl-23606127
T-2 toxin, a toxic member of the group A trichothecenes, is produced by various Fusarium species that can potentially affect human health. As the intestine plays an important role in the metabolism of T-2 toxin for animals and humans, the degradation and metabolism of T-2 toxin was studied using the pig cecum in vitro model system developed in the author's group. In order to study the intestinal degradation of T-2 toxin by pig microbiota, incubation was performed with the cecal chyme from four different pigs in repeat determinations. A large variation in the intestinal degradation of T-2 toxin was observed for individual pigs. T-2 toxin was degraded almost completely in one out of four pigs, in which only 3.0 ± 0.1 % of T-2 toxin was left after 24 h incubation. However, in the other three incubations with pig cecal suspension, 54.1 ± 11.7-68.9 ± 16.1 % of T-2 toxin were still detectable after 24 h incubation time. The amount of HT-2 toxin was increased along with the incubation time, and HT-2 toxin accounted for 85.2 ± 0.7 % after 24 h in the most active cecum. HT-2 toxin was the only detectable metabolite formed by the intestinal bacteria. This study suggests that the toxicity of T-2 toxin for pigs is caused by the combination of T-2 and HT-2 toxins.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxina T-2 / Ceco / Modelos Biológicos Limite: Animals / Humans Idioma: En Revista: Mycotoxin Res Ano de publicação: 2012 Tipo de documento: Article País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxina T-2 / Ceco / Modelos Biológicos Limite: Animals / Humans Idioma: En Revista: Mycotoxin Res Ano de publicação: 2012 Tipo de documento: Article País de publicação: Alemanha